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Use of illegal drugs and supplements in competitive bodybuilding has received considerable attention in recent years, in spite of its adverse health effects. A number of clinical trials have demonstrated that, in conjunction with other medical conditions or treatment regimens, illegal drugs might decrease the body's ability to repair and improve tissue damage after muscle damage [ 8 ]. This may contribute to increased skeletal muscle protein anabolic responses [ 10 ], buy anabolic steroids uk online. Other studies point to the involvement of methamphetamine in muscle damage; methamphetamine is a relatively new stimulant with high plasma concentrations that induces muscle damage. Its stimulant properties increase the production of testosterone [ 11 ], best bodybuilding supplement brands. For instance, amphetamines, the most widely prescribed form of methamphetamine, show a stimulant effect on testosterone levels [ 12 , 13 ], buy anabolic steroids uk online. In addition, amphetamines have also been linked to increased muscle damage and increased intracellular cAMP [ 14 ]. A recent review in the American Journal of Clinical Nutrition [ 15 ] concluded that amphetamines have anti-diabetic actions, increase skeletal muscle protein synthesis, increase muscle protein breakdown at rest [ 16 ] and increase the rate of muscle protein synthesis during endurance exercise [ 17 ]. A number of published studies in humans have demonstrated that methamphetamine use may decrease the strength of skeletal muscle during an exercise bout [ 14 , 15 , 18 - 21 ], supplements drugs bodybuilding. For example, in the majority of a recent study conducted with healthy males with a body weight of 100 kg we found that users of methamphetamine and caffeine reported higher voluntary strength and power as measured by the Smith machine [ 21 ], drugs supplements bodybuilding. Moreover, methamphetamine users reported an increase in the amount of time that the participants could perform at 90% of their maximal voluntary torque during a 1:3 repetition maximum strength exercise [ 22 ]. Body weight is a surrogate measure of muscle mass, where it is calculated by dividing body weight by maximal squat strength [ 7 ]. Therefore, a difference of body weight per 10 kg increases the rate of muscle building over several months by approximately 8%, i.e. a 24% gain (i.e. 8 g·kg−1·min−1 vs. 4 kg·kg−1·min−1), i.e. a total of ~120 g·kg−1·month−1 (8 kcal·kg−1·month−1 g·kg−1·week−1). The effect of methamphetamine use on muscle mass is particularly clear in athletes, who are more apt to ingest methamphetamine due to its stimulant properties, whereas other drugs, such as amphetamines, are less likely to cause muscle damage such as muscle fiber damage [ 8 ], buy anabolic steroids uk online.


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